188体育平台

注射用牛肺表面活性剂说明书

qingzixiyuedushuomingshubingzaiyishizhidaoxiashiyong

【yaopinmingcheng】

188体育平台　　tongyongmingcheng: zhusheyongniufeibiaomianhuoxingji

　　shangpinmingcheng: kelisu

188体育平台　　yingwenmingcheng: calf pulmonary surfactant for injection

　　hanyupinyin: zhusheyong niu feibiaomianhuoxingji

【chengfen】

　　benpinshicongjiankangxinshengxiaoniufeizhongfenlitiqudefeibiaomianhuoxingwuzhi。zhuyaozufenbaokuolinzhi、danguchun、ganyousanzhi、youlizhifangsuanheshaoliangfeibiaomianhuoxingwuzhidanbai（sp-bhesp-c），qizhongzonglinzhibushaoyu80％，luanlinzhibushaoyu55％，danbaihanliangyue1~2％。ciwai，benpinmeipinghanyouxiangdangyu2mlputaotanglvhuanazhusheye（5％putaotang，0.9％lvhuana）deganzaowu。

188体育平台　　fuliaowei: putaotanglvhuanazhusheye。

【xingzhuang】

　　benpinweibaisezhileibaisedeshusongkuaizhuangwu。

【shiyingzheng】

　　yongyuzhiliaoxinshengerhuxijiongpozonghezheng（rds），yijiyufangzaochanyingerhuxijiongpozonghezheng。

【guige】

　　70mg

【yongfayongliang】

　　benpinjinnengyongyuqiguanneijiyao。

　　jiyaoshijian:

　　yufangxingyongyao: shiyongyutailingxiaoyu29zhouhe/huocunzaixinshengerhuxijiongpozonghezhengfengxiandezaochaner，zaichushenghouyingjinzaojiyao，zuihaozaichushenghou30fenzhongnei；

188体育平台　　zhiliaoxingyongyao: yaozaichuxianrdszaoqizhengxianghoujinzaojiyao，tongchangzaihuanerchushenghou12xiaoshiyinei，buyichaoguo48xiaoshi，jiyaoyuezaoxiaoguoyuehao。

　　jiliang: 70mg/kgchushengtizhong，jiyaojiliangyinggenjuhuanerjutiqingkuanglinghuozhangwo，shoucijiyaofanweikezai40～100mg/kgchushengtizhong，duoshubinglirunengzaoqijishiyongyao，70mg/kgjikequdelianghaoxiaoguo；bingqingjiaozhong，xiongpianbingbianmingxian，dongmaixueyangfenyajiaodi，huoyouhebingzhengdebingli，piandajiliangkeyougenghaoxiaoguo。

　　yongfa: yingyongqianjianchayaopinwaiguanyouwubianse，meizhijia2mlzhusheyongshui，jiangyaopinfuwendaoshiwen（kezaishiwenfangzhi20fenzhonghuoyongshoufuwen），qingqingzhendang，wuyongliyaodong，shichengjunyundehunxuanye，ruoyoushaoliangpaomoshuzhengchangxianxiang。anjiliangchouxiyu5mlzhusheqinei，yixisuliaodaoguanjingqiguanchaguanzhurufeinei，charushenduyigangdaoqiguanchaguanxiakouweiyi。zongjiliangfen4ci，anpingwo、youcewo、zuocewo、banwoweishunxuzhuru。meicizhurushijianyuewei10～15miao，zhurusudubuyaotaikuai，yimianyaoyeqiangchuhuodusaiqidao，meicijiyaojiangejiayajiyang（pinlv40－60ci/fen）1～2fenzhongzuoyou（zhuyiwuqiliangguodayimianfashengqixiong），zhuyaoquanguochengyue15fenzhong。jiyaocaozuoyingyou2mingyiwurenyuanhezuowancheng，zhuyaoguochengzhongyingmiqiejiancehuanerhuxixunhuanqingkuang，feibutingzhenkeyouyiguoxingshaoliangshuipaoyin，bubizuoteshuchuli。jiyaohou4xiaoshineijinkenengbuyaoxitan。

188体育平台　　jiyaocishu: duoshutongchangzhiyingyong1cijike，ruhuanerhuxiqingkuangwumingxianhaozhuan，xujixuyingyonghuxiji，mingquehuxishuaijieshiyourdsyinqi，biyaoshizaidiyiciyongyaohou12～24xiaoshi（zhishao6xiaoshi）keyingyongdi2ci，zhongfujiyaozuiduoyingyong3ci，jiliangyushoucijiyaoxiangtong。

【buliangfanying】

　　linchuangshangjiyaocaozuoguochengzhongyouyuyiguoxingqidaozusaikeyouduanzandexueyangxiajianghexinlv、xueyabodong，fashengbuliangfanyingshiyingzantingjiyao，jiyixiangyingchuli，bingqingwendinghouzaijixujiyao。

　　genjulinchuangshiyan，benpinjiyaocaozuoguochengzhongyouyuqidaobufenzusaifashenglinchuangzhengzhuangzhegongzhan33.3％，qizhongfashengyiguoxingzigan21.1％，qiangke8.8％，huxizanting3.5％，yishangzhengzhuangzaiyaoyezhubi，shoukongtongqi1fenzhong，yaowufenbuyufeipaoneihoujixiaoshi，weijianguominfanyingjiqitabuliangfaying。

188体育平台　　jiyaohoufeishunyingxingkezaiduanshijianneihaozhuan，yingjishidiaodihuxijitongqiyali，yimianfashengfeitongqiguoduhuoqixiong；xiruyangnongduyeyaogenjuxueyangbianhuaxiangyingdiaozheng。

188体育平台　　genjubenpinlinchuangshiyanjieguo，yongyaosantianhouxueyeshenghuajiancha，duigan、shengongnengwuzhongyaoyingxiang。

　　benpin（kelisu）shangshihoubuliangfanyingjiancejieguoweijianqitabuliangfanyingbaogao。

　　genjuguowaiwenxianbaodao，tongleipinzhonglinchuangshiyanjieguoxianshijiyaocaozuoxiangguandechangjianbuliangfanyinghaibaokuo: xindongguohuan（34%），biaomianhuoxingwuzhifanliuzhiqiguandaoguan（21%），xuyaoshoukongtongqi（16%）yijizhongxinqiguanchaguan（3%）。zheixieshijiantongchangweiduanzanfashengqiebuhuibansuiyouyanzhongdebingfazhenghuosiwang。ciwai，suizhejiyaocaozuojishudejinzhan，guoneitongleipinzhonghenshaobaodaoyouxindongguohuan、dixueya、diyangbaohedu、zanshixingdenaodianhuodongjianruo。feichuxuehanjian，danyoushishizaochanerzhimingdebingfazheng，fayuyuebuchengshudezaochanerfabinglvyuegao；wurenhezhengjubiaomingshiyongfeibiaomianhuoxingwuzhinengzengjiagaishijiandeweixianxing。

【jinji】

　　benpinwuteshujinji，youqixionghuaneryingxianjinxingchuli，ranhouzaijiyao，yimianyingxianghuxijideyingyong。

【zhuyishixiang】

　　1.benpinjinkeyongyuqiguanneijiyao，yongyaoqianhuanerxujinxingqiguanchaguan。

　　2.benpindeyingyongyaozaiyouxinshengerhuxijijiujingyandeyishizhidaoxiajinxing，bingyangezunshouyouguanxinshengerjijiuguifandecaozuoguicheng。benpindeyingyongzhiyouzaiwanshandexinshengerzonghezhiliaoheyoujingyandehuxijijiugongzuojichushangcainengchenggong，tebieshihuxijideyingyong。

　　3.weishibenpindehunxuanyejunyun，jiashuihouyoushixuzhendangjiaozhangshijian（10fenzhongzuoyou），danwuyongqiangli，bimianchanshengguoduopaomo，danyoushaoliangpaomoshuzhengchangxianxiang。zhuyiwujianghunxuanyezhongdexiaokelizhuruqiguan。

　　4.jiyaoqianyaoquebaoqiguanchaguandeweizhishizhong，wucharuguoshen，yifangyaoyezhiliuruyouce，tongshiyaobaochiqidaochaguandetongchang，biyaoshiyuyixiyin。

188体育平台　　5. yingbaozhengyingerdeyibanzhuangtaiwending。jiuzhengsuanzhongdu、dixueya、pinxue、dixuetangheditiwen。jiyaoqijianhuanerkenenghuifashengxindongguohuan、feibiaomianhuoxingwuzhifanliuzhiqiguanchaguan、qidaozusai、zigan、qiguanchaguanyichuhuohuanqibuzu。ruguofashengshangshurenheshijian，kezhongduanzhiliaobingcaiqushidangdecuoshi。denghuanerqingkuangwendinghourengkeyizaishidangjianhuxiashiyongbenpin。

　　6.zhunbeiyongbenpinzhiliaodehuaner，jiyaoqianyingyonghuxijidecanshuyipiandi，zhuyiyaliwuguogao，yinbiaomianhuoxingwuzhiquefadefei，henrongyiyinfeiqiangzhikuozhangersunshang。jiyaohouhuxijidediaojieshibingqingerding，dazhihuxipinlvzai40－60ci/fen，xiqishijian0.5miaozuoyou。

188体育平台　　7.jiyaohouyanghezuoyonghefeishunyingxing（jifenzhongdao1xiaoshi）henkuaihaozhuan，yingjishijianchaxueqi，diaozhenghuxijicanshu（yali、yangnongdu），yimiantongqiguoduhuoxueyangguogao。zairenzhenjianhuxia，yangliaohetongqizhichikeyigenjuhuxizhuangtaidebianhuaerjinxingdiaozheng。

　　8.shiyongbiaomianhuoxingwuzhikeyijianqingrdsdeyanzhongchengdu，huojiangdiqifabinglv。danshizaochanyingerkenengyinfayubuquaneryouqitahebingzheng，yincibukenengwanquanxiaochuyuzaochanyouguandebingsilvhefabinglv。yingxiangliaoxiaodeyinsujiaoduo，jutongji，yingyongfeibiaomianhuoxingjizhiliaoderdshuaner50～75%youjikechijiufanying，10～20%youzanshixiaoguo，lingwai15～25%duizhiliaowufanying。tebieshijiditizhonger，feichengshuduchufeibiaomianhuoxingwuzhiwaishangyoufeixueguanhefeijiedizuzhidengfangmianwenti，zhixihuanerchangjianjinjuyouzanshixiaoguo。yingerruguozaizhangshijianpomo（chaoguo3zhou）houfenmian，kenengfeibufayubuliangheduiwaiyuanxingbiaomianhuoxingwuzhifanyingbujia，suoyiyingtebiexiaoxin。ciwai，jiyaokaishideshijian、jiliang、huxijidediaojie，chanqianmuqinshifouyingyongjisudouhuiyingxiangzhiliaoxiaoguo。

　　jiyaohoubingqinggaishanbumingxianshiyaokaolvhuxijiongpodeqitayuanyin，ruqixiong，dongmaidaoguanzhongxinkaifangdeng。

　　9.feibiaomianhuoxingwuzhidemiehuo（inactivation）: feibiaomianhuoxingwuzhidemiehuohuoyizhishizhiliaoshibaideyigezhongyaoyuanyin。zairdsbingchengzhong，tebiezaihouqi，gezhongyuanyinchanshengdefeisunshangkedaozhifeibiaomianhuoxingwuzhidemiehuo。miehuokeyoufeishangpisunshangshixuejiangneishenchuchengfen（ruxuejiangdanbai、xianweidanbaiyuan），yanxingchanwu，taifendengyinqi。tamenkeganraofeibiaomianhuoxingwuzhidelinzhihuodanbaidegongneng，qizhongyouxiekeni，youxiebukeni。miehuodejizhishiduoyangde，kepohuaifeibiaomianhuoxingwuzhizaifeipaobiaomianxingchengdedanfenziceng，kegaibianlinzhiyudanbaidexietongzuoyong，kejianglinzhifenjiehuozaochengdanbairongjie（proteolysis）。hanyoudanbaidefeibiaomianhuoxingwuzhizhiji，youyidingdedikangyizhinengli，youyubutongfeibiaomianhuoxingwuzhizhijidanbaichengfendechayi，qidikangyizhinenglibutong。zaifeibiaomianhuoxingwuzhizhiliaozhong，dangyizhixianxiangfashengshi，ketongguozengjiafeibiaomianhuoxingwuzhizhiliaodejilianghecishu，yijianqingyizhideyingxiang。

188体育平台　　10.feibiaomianhuoxingjizhiliaodeyuanqixiaoguo: genjuguowailinchuangbaogao，yingyongfeibiaomianhuoxingji（dongwuzhiji）hou2nianyishanglinchuangzhuizongdejieguo，yuduizhaoxiangbi，yingyongfeibiaomianhuoxingjihuanerweifaxianyougengduodeguominxingjihuan（shizhen、xiaochuan、niunaiguomindeng）；zaitige、shenjing、zhilidefayujihuanhuxidaoganrandecishu，junyuduizhaozuwuchabie。

　　11.genjuguowaiziliao，yingyongniufeibiaomianhuoxingwuzhidexinshenger，you2.6%chanshengteyidanbaikangti，danqizhong1/3zaiyongyaoqianjiyicunzai。kangtichanshengjihuibuduodeyuanyinyuniuherenfeibiaomianhuoxingwuzhidanbaianjisuanxuliejiweixiangjinyouguan。tongguodalianglinchuangguancha，zhijinmeiyouyingyongfeibiaomianhuoxingjiyinqiyanzhongguomindelinchuangbaogao。

188体育平台　　12.benpinkaiqihouyingzai24xiaoshineiyingyong。

188体育平台【yunfujiburuqifunvyongyao】

188体育平台　　benpinbushiyongyuyunfujiburuqifunvyongyao。

【ertongyongyao】

　　xiangjian【shiyingzheng】he【yongfayongliang】。

【laonianyongyao】

　　benpinbushiyongyulaonianren。

【yaowuxianghuzuoyong】

188体育平台　　zaochanerdemuqinchanqianyingyongtangpizhijisu，kecujinfeijiegouhegongnengdechengshu，zengjiafeibiaomianhuoxingwuzhidefenmi，tigaobenpindezhiliaoxiaoguo。

【yaowuguoliang】

　　jixingdaliangfeibiaomianhuoxingwuzhizhuruqiguanneikedusaihuxidao，zaochengtongqizhangai；lianxuduorifeineizhurudaliangfeibiaomianhuoxingwuzhi，keyinqitunshixibaorouyazhongheyanzheng。

【yaoliduli】

　　yaolizuoyong: benpinzhuyaozuoyongshijiangdifeipaoqi-yejiemianbiaomianzhangli，baochifeipaowending，fangzhifeibuzhang。juwenxianbaodao，zaibanyouhuxizhangaidezaochaner，feibiaomianhuoxingwuzhiyoushifeipaokuozhanghewendingdezuoyong，kegaishanfeideshunyingxingheqitijiaohuan。

188体育平台　　duliyanjiu: chengnianjiatuan80mg/kgqiguanneilianxujiyubenpin4tian，feineikejianzhongduyanzhenghejiaoduohankongpaodetunshixibao。zaiyoutuan80mg/kgqiguanneilianxujiyubenpin7tian，youqingdaozhongduyanzheng，yizhouhoudadouhuifu；ciwaihaikejianbutongdetunshizhizhifanying，baokuotunshixibaojinrun、tunshixibaorouyazhonghetingyaoyizhouhoudexianweihuaxiaojiedeng。

【yaodaidonglixue】

188体育平台　　youyufeibiaomianhuoxingwuzhishidongwutineiguyoude，shichengfenshifenfuzadewuzhi，qiezhuyaozaifeipaobiaomianqizuoyong，nanyizaidongwutineijinxingyaodaidonglixueyanjiu。juwenxianziliao，feipaochibiaomianhuoxingwuzhiqingchutujingyouduozhongkeneng，qizhongxiangdangbufenweifeipaoⅱxingxibaoshequ，jinrubancengxiaotizhongxinliyong，qishengwubanshuaiqizaibutongqingkuangxiachayijiaoda，feipaochiluanlinzhiquanbugengxinshijianwei3～11xiaoshi。benpindiruqiguanhou，bufenzaifeipaofahuizuoyong，qitazejinrufeizuzhijinxingzaixunhuan，zailiyong。qidaixiezhuyaozaifeinei，jibenshangbujinrutineiqitabufenjinxingdaixie。benpindefeineiqingchuanyijidonglixuejinxing。

【zhuzang】

　　mifeng，-10℃yixiabaocun。

【baozhuang】

188体育平台　　boliguanzhizhushejiping，1zhi/he。

【youxiaoqi】

　　zanding18geyue。

【zhixingbiaozhun】

188体育平台　　guojiayaopinbiaozhunybh31212005

【pizhunwenhao】

188体育平台　　guoyaozhunzih20052128

【shengchanqiye】

188体育平台　　qiyemingcheng: huarunshuangheyaoyegufenyouxiangongsi

　　shengchandizhi: beijingshichaoyangqushuangqiaodonglu2hao

　　youzhengbianma: 100121

　　dianhuahaoma:

　　chuanzhenhaoma:

　　wang zhi: moneycomeon.com.cn